He is accused of multiple homicides in the region, participated in the escape of 21 prison inmates in Apatzingán, Michoacan in 2004. Santiago coordinated the human trafficking and smuggling of South and Central Americans into the U.S.
Santiago is considered one of the co-founders of the Zetas and worked along Oziel Cárdenas Guillén, the former leader of the Golf Cartel. Guillén is serving at least 25 years in a federal prison in the U.S."
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